Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle-invasive bladder cancer

Background Tumor-associated macrophages (TAMs) secreting IL-10 could be a specific functional cell subset with distinct polarization state and suppressive role in antitumor immune response.Here, we assessed the associations of clinical outcome, therapeutic responses and molecular features with IL-10+TAMs infiltration, and potential impact of IL-10+

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The occurrence of disinfectant and antibiotic-resistant genes in Escherichia coli isolated from chickens in Egypt

Aim: This work aimed to determine the occurrence of antibiotic and disinfectant resistance genes in Escherichia coli isolated from chickens in Egypt.Materials and Methods: Organs (liver, lung, heart, yolk sac, and bone marrow) of 1500 chicken samples were collected from diseased chickens suffered from colibacillosis with PM findings as CRD, diarrhe

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Keberlakuan dan Penerapan Undang-Undang Nomor 1 Tahun 2022 tentang Hukum Keuangan Pemerintah Pusat dan Pemerintahan Daerah sebagai Upaya Perwujudan Pemerataan Kesejahteraan Rakyat

Since Law Number 1 Caster Accessories of 2022 has existed in society, it has provided a number of implications including in the implementation of regional autonomy and decentralization.The scope of law reform which covers taxes and levies, management of transfers to the regions, management of regional expenditures, granting authority to carry out r

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